Description
It is known that adult neurogenesis, the production of new neurons in certain areas of the brain, decreases with age, and the loss of neurogenic potential is associated with Alzheimer’s disease (AD).The main role in neurogenesis is played by growth factors and neurotrophins, which act at different stages of neurogenesis, and their concentration can be regulated by other modulating factors.
P21 is a relatively new peptide that was developed based on research on Cerebrolysin. P21 is a peptide that was developed by reverse engineering the action of Cerebrolysin using epitope mapping. According to the study, P21 works much better than Cerebro because the Ten peptide is a mimetic of CTNF, the factor to which Cerebrolysin mainly owes its action. P21 is a neurogenic and neurotrophic compound that enhances cortical neurogenesis and memory processes by inhibiting the leukemia inhibitory factor (LIF) signaling pathway and increasing the expression of brain-derived neurotrophic factor (BDNF).
Ciliary neurotropic factor (CTNF) exhibits a number of actions within the nervous system. It is a neurotrophic growth factor that affects the differentiation of developing neurons and glial cells; it increases the survival (viability) of neurons of the peripheral and central nervous system. Experimental studies have shown that CNTF promotes the survival and differentiation of neural, motor, sensory and sympathetic cells. Numerous studies show that It plays a very important role in nerve regeneration after damage. The repair capabilities are due to the fact that the factor is produced by Schwann cells and astrocytes next to the cut nerve.
